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1.2 Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake

JH Jeong , DK Lee , SM Liu , SC Chua , GJ Schwartz , YH Jo

To read the full abstract: PLoS Biol 2018;16:e2004399The hypothalamus plays a central role in the control of numerous physiological pathways and received afferent pathways from the brain and from the periphery. For instance, body temperature changes in peripheral tissues are conveyed to the hypothalamus via the bloodstream. An increase of temperature within the hypothalamus results in an i...

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ey0020.9-6 | Advances in Understanding Central Weight Regulation and Behaviour | ESPEYB20

9.6. Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior

Y He , B Brouwers , H Liu , K Lawler , EM de Oliveira , DK Lee , Y Yang , AR Cox , JM Keogh , E Henning , R Bounds , A Perdikari , V Ayinampudi , C Wang , M Yu , L Tu , N Zhang , N Yin , J Han , NA Scarcelli , Z Yan , KM Conde , C Potts , JC Bean , M Wang , SM Hartig , L Liao , J Xu , I Barroso , J Mokrosinski , Y Xu , IS Farooqi

Brief summary: This collaborative study identified 13 monoallelic rare loss-of-function (LoF) variants in the serotonin 2C receptor (HTR2C) gene in 19 unrelated individuals with hyperphagia, severe early-onset obesity, and some degree of maladaptive behaviour. The authors used exome sequencing in 2548 individuals with severe obesity and 1117 control individuals without obesity. They found that HTR2C variants cause monogenic obesity by demonstrating t...

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ESPE Yearbook of Paediatric Endocrinology

1.2 Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake

9.6. Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior

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